5 edition of Microbial and Plant Cytochromes P-450 found in the catalog.
by Taylor & Francis Group
Written in English
|Contributions||Horst Rein (Editor)|
|The Physical Object|
|Number of Pages||240|
Cytochrome P proteins, named for the absorption band at nm of their carbon-monoxide-bound form, are one of the largest superfamilies of enzyme proteins. The P genes (also called CYP) are found in the genomes of virtually all organisms, but their number has exploded in plants. Their amino-acid sequences are extremely diverse, with levels of identity as low as 16% in some Cited by: F. P. Guengerich () Common and Uncommon Cytochrome p Reactions Related to Metabolism and Chemical Toxicity. Chemical Research in Toxicol P. Anzenbacher and E. Anzenbacherova () Cytochromes p and Metabolism of Xenobiotics. Cellular and Molecular Life Scien F. P. Guengerich () Cytochrome p Enzymes.
[Read] Plant Genetic Engineering For Online. hocupip. Follow. 11 months ago | 0 view. Collection Book Plant Protoplasts and Genetic Engineering II (Biotechnology in Agriculture and Download Microbial and Plant Cytochromes P Biochemical Characteristics Genetic Engineering. Ahmad Agha. The group has been intensively studied because mutations of the cytochrome P gene have been found to be associated with a number of diseases including Addison's disease, liver cancer and Parkinson's disease. Cytochrome P can also interfere with drug treatment.
Of seven cDNA-expressed human cytochrome P (P) enzymes (Ps 1A2, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4) examined, P 1A2 was the most active in catalyzing 2- . Understanding pesticide metabolism in plants and microorganisms is necessary for pesticide development, for safe and efficient use, as well as for developing pesticide bioremediation strategies for contaminated soil and water. Pesticide biotransformation may occur via multistep processes known as metabolism or by:
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The microbial Ps perform an array of oxidative and other chemical reactions that are both crucial for the viability of the bacterial, archaeal, and fungal hosts, and which have numerous.
ISBN: X OCLC Number: Description: ix, pages: illustrations: Contents: Distribution and diversity of bacterial cytochromes P / O. Asperger and H.-P. Kleber --Molecular recognition by cytochrome Pcam: substrate specificity, catalysis and electron transfer / S.A. Martinis [and others] --Cytochromes P in alkane.
Reduced P can bind carbon monoxide instead of oxygen. CO coordination results in a shift of the maximum of absorbance of the heme to nm (Omura and Sato, ) and thus leads to the name Pigment absorbing at nm (P).This property is characteristic of P enzymes and when CO is bound with high affinity it prevents binding and activation of O 2.
Time course of induction of cytochrome P, NADPH-cytochrome c reductase and cinnamic acid hydroxylase by phenobarbital, ethanol, herbicides and manganese in higher plant microsomes. Plant Physiol. –Cited by: The first eukaryote genome revealed three yeast cytochromes P (CYPs), hence the subsequent realization that some microbial fungal genomes encode these proteins in 1 per cent or more of all.
The first eukaryote genome revealed three yeast cytochromes P (CYPs), hence the subsequent realization that some microbial fungal genomes encode these proteins in 1 per cent or more of all genes (greater than ) has been by: Kelly S, Kelly D, Jackson C, Warrilow A, Lamb D () The diversity and importance of microbial cytochromes P In: Ortiz de Montellano PR (ed) Cytochrome P structure, mechanism and biochemistry, 3rd edn.
Kluwer Academic/Plenum Publishers, New York, pp – Google ScholarCited by: 8. There are cytochrome P genes (and 28 pseudogenes) in the Arabidopsis genome. Ps thus form one of the largest gene families in plants.
Contrary to what was initially thought, this family diversification results in very limited functional redundancy and seems to mirror the complexity of plant metabolism. Ps sometimes share less than 20% identity and catalyze extremely diverse.
Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Cytochrome P aromatic O-demethylase, which is made of two distinct promiscuous parts: a cytochrome P protein (GcoA) and three domain reductase, is significant for its ability to convert Lignin, the aromatic biopolymer common in plant cell walls, into renewable carbon chains in a catabolic set of reactions.
In short, it is a facilitator of InterPro: IPR Cytochrome P Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P to its relevance in human medicine.
Cytochromes are divided into three main groups, the cytochromes-a, -b, and correspond to heme-a, -b, and -b may be regarded as the basic structure (Fig.
).In heme-c the -SH-group of a cysteine is added to each of the two vinyl groups of this way heme-c is covalently bound by a sulfur bridge to the protein of the cytochrome. Cytochromes P are a superfamily of cysteine thiolate-ligated heme-containing monooxygenase enzymes that catalyze the transfer of an oxygen atom from molecular oxygen into a wide variety of biological substrates, with the second oxygen atom being reduced by two electrons to a water molecule (Equation (1)).
1–10 Cytochrome P enzymes have been isolated from mammalian tissues, birds. Maughan, J. A., Nugent, J. A., Clark, I. M., Westlake, A. and Hallahan, D. Molecular enzymology of plant cytochromes P Proceedings Brighton Crop Author: J.
Maughan, J. Nugent, I. Clark, A. Westlake, D. Hallahan. Cytochromes P Metabolic and Toxicological Aspects examines cytochrome P proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to: Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicityCited by: Reductive reactivities of microbial and mammalian cytochromes P compared with heme and whole-cell models Charles E.
Castro, Wallace H. Yokoyama, and Nao O. Belser J. Agric. Food Chem.,36 (5), pp – This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field.
Thirteen chapters are divided into Price: $ Get this from a library. Cytochrome P structure, mechanism, and biochemistry. [Paul R Ortiz de Montellano;] -- This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P enzymes, with.
Cytochrome P in plant/insect interactions: geraniol hydroxylase and the biosynthesis of iridoid monoterpenoids. Drug Metabolism and Drug Interactions. 12, pp. Genetic manipulation of photosynthesis to reduce crop fertiliser requirements: photosynthesis growth and allocation at low nitrogen in transgenic tobacco with reduced Cited by: 5.
Plants use a diverse array of cytochrome P monooxygenases in their biosynthetic and detoxification pathways. To determine the extent to which various maize Ps are induced in response to chemical inducers, such as naphthalic anhydride (NA), triasulfuron (T), phenobarbital, and bacterial pathogens (Erwinia stuartii, Acidovorax avenae), we have analyzed the response patterns of seven Cited by:.
During his time in Illinois, Gunsalus developed a genetic system for the study of Pseudomonas, dissected the step pathway for terpene breakdown, discovered the first three-component microbial cytochrome P system involved in this pathway, and purified and crystallized the hemoprotein component of cytochrome P Cytochrome P enzymes are primarily found in liver cells but are also located in cells throughout the body.
Within cells, cytochrome P enzymes are located in a structure involved in protein processing and transport (endoplasmic reticulum) and the energy-producing centers of cells (mitochondria). The enzymes found in mitochondria are.The prokaryotic phylum Cyanobacteria are some of the oldest known photosynthetic organisms responsible for the oxygenation of the earth.
Cyanobacterial species have been recognised as a prosperous source of bioactive secondary metabolites with antibacterial, antiviral, antifungal and/or anticancer activities.